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Several enzymatic pathways are involved in protecting cells against 4HNE injury

For example, when a respiratory viral infection is combined with invasive fungal disease, cytokines attract more immune cells, which in turn produce more cytokines, creating an inflammatory cycle that damages lung tissues and causes the formation of fibrin and scar tissue, which allows fluids to seep into and fill the lung cavities, leading to respiratory failure (66)

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doi: 10.2337/db08-0604 101 XuLSpinasGANiessenM

[DOI] [Google Scholar] 23.Yin N

Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress